Bone Biology Research Program
The Bone Research Program pursues research in Basic Bone Biology, Applied Bone Metabolism and Clinical Research in Metabolic Bone Disease. Our laboratory has a strong interest in the development and evaluation of transgenic models of bone disease.
A number of exciting and competitive projects are presently under way (see also below). Within this framework, we have established collaborations with research groups in Australia based at the Universities of Sydney, New South Wales, Melbourne, Adelaide, Perth and Brisbane. Internationally, we collaborate with colleagues from Columbia University, New York, USA, the Universities of Heidelberg, Berlin and Wuerzburg, Germany, The Rowett Research Institute at Aberdeen University, UK, the University of Basel, Switzerland, and many others.
We have been successful in building close research partnerships through attracting visiting scientists to work with us at the Bone Research Program. In 2005/2006 we welcomed Dr Efrat Monsonego Ornan from Tel Aviv, Israel, Professor Frank Buttgereit from Humboldt University Berlin, Germany, and Dr Di Chen from the University of Rochester, NY, USA. In 2007 and 2008, we are expecting visiting fellows from England, Germany, Brasil and the US.
Our research is supported through funding from within Australia and from overseas. Together with our collaborators, we have attracted funding to a total value of over AUD 5 million, including six current NHMRC project grants.
Our plan is to further develop a comprehensive research program that makes use of the multidisciplinary opportunities provided the ANZAC Research Institute. Our goal is to intensify collaborations with both basic and clinical research groups on the ARI and Concord campus, and to extend our research efforts to other areas relevant to bone biology and disease.
Our major research projects are:
Preventing The Spread Of Malignant Tumours To Bone
Yu Zheng, Li Laine Ooi, Julie Blair, Hong Zhou, Colette Yee, James Modzelewski, Markus Seibel, Colin Dunstan.
Details here.
Glucocorticoid-Induced Changes in Bone Metabolism
Wendy Mystie Mak, Colette Yee, Janine Street, Colin Dunstan, Markus Seibel, Hong Zhou.
Details here.
Regulation of osteoblast and adipocyte differentiation from common precursors
Hong Zhou, Robert Kalak, Wendy Mystie Mak, Colette Yee, Janine Street, Colin Dunstan, Markus Seibel.
Details here.
Study into the genetic determinants of bone loss and osteoporosis
Marta Koslowska, Christian Meier, Marina Kennerson, James Modzelewski, Garth Nicholson, Ian Blair, Markus Seibel.
Details here.
Studies on Bone Metabolism and Calcium Homoestasis
James Modzelewski, Christian Meier, Markus Seibel.
Details here.
Studies into the influence of sex hormones and their longitudinal changes on different target tissues of androgen action
Christian Meier, Mark Jimenez, James Modzelewski, David J Handelsman, Markus Seibel.
Details here.
